Plasma homovanillic acid in schizophrenia implications for presynaptic dopamine dysfunction

Cover of: Plasma homovanillic acid in schizophrenia |

Published by American Psychiatric Press in Washington, DC .

Written in English

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Subjects:

  • Schizophrenia -- Pathophysiology.,
  • Homovanillic acid -- Analysis.,
  • Blood plasma -- Analysis.,
  • Dopamine -- Physiological effect.,
  • Schizophrenia -- physiopathology.,
  • Homovanillic Acid -- blood.,
  • Dopamine -- metabolism.

Edition Notes

Includes bibliographical references and index.

Book details

Statementedited by Arnold J. Friedhoff and Farooq Amin.
SeriesProgress in psychiatry, Progress in psychiatry series.
ContributionsFriedhoff, Arnold J., 1923-, Amin, Farooq, 1955-
Classifications
LC ClassificationsRC514 .P56 1997
The Physical Object
Paginationxv, 197 p. :
Number of Pages197
ID Numbers
Open LibraryOL991717M
ISBN 100880484896
LC Control Number96030139

Download Plasma homovanillic acid in schizophrenia

The role of dopamine in schizophrenia has been a significant area of research. The measurement of the major dopamine metabolite, homovanillic acid (HVA), in various body fluids, especially in blood plasma, is one of the primary methods to assess brain dopamine neuronal activity in schizophrenic Format: Hardcover.

The role of dopamine in schizophrenia has been a significant area of research. The measurement of the major dopamine metabolite, homovanillic acid (HVA), in various body fluids, especially in blood plasma, is one of the primary methods to assess brain dopamine neuronal activity in schizophrenic.

Plasma homovanillic acid in the prodromal phase of schizophrenia. Abstract Elevated levels of plasma homovanillic acid (HVA) are associated with increased psychopathology after neuroleptic withdrawal in schizophrenia, and may be predictive of treatment response in psychotic patients.

There are limited extant data on plasma HVA in psychotic and non‐psychotic major by: 1. Plasma homovanillic acid concentration was assessed in 60 young schizophrenic patients, with and without first‐degree relatives with schizophrenia, before treatment, and 3 days after starting haloperidol treatment.

The baseline concentration of homovanillic acid in plasma was no different in the two groups before treatment; it was, however Cited by: 5. Plasma levels of homovanillic acid (pHVA), a metabolite of dopamine (DA), have been regarded as a peripheral indicator of central DA activity and have been the subject of extensive studies investigating several aspects of DA dysfunction in schizophrenia (see Plasma homovanillic acid in schizophrenia book and Amin for review).Cited by: Request PDF | Plasma homovanillic acid in untreated schizophrenia -- Relationship with symptomatology and sex | Plasma homovanillic acid (pHVA) concentrations are considered to.

In contrast, a fixed dose of haloperidol did not affect those concentrations. Thus, in patients with a diagnosis of schizophrenia, plasma homovanillic acid may reflect the severity of illness, but not be influenced by short-term pharmacological perturbations by by: Plasma homovanillic acid (pHVA) concentrations are considered to reflect, in part, central dopamine metabolism and thus may be of value in assessing the role of dopamine neurotransmission in schizophrenia.

Furthermore, some recent studies have suggested Cited by: W. Verhoeven Background: Psychosis spectrum disorders, especially schizophrenia, have been linked to disturbed dopaminergic activity Plasma homovanillic acid in schizophrenia book the brain.

Plasma homovanillic acid (pHVA) levels. Homovanillic acid (HVA) is a major catecholamine metabolite that is produced by a consecutive action of monoamine oxidase and catechol-O-methyltransferase on dopamine. Homovanillic acid is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain.

In psychiatry and neuroscience, brain and cerebrospinal fluid levels of HVA are measured as a marker of metabolic CAS Number:   We have determined the plasma (p) concentration of gamma-aminobutyric acid (GABA) and the dopamine metabolite homovanillic acid (HVA), and the pHVA/pGABA ratio in schizophrenic and bipolar patients.

The research was undertaken in a geographic Cited by: Homovanillic acid (HVA) is the major metabolic product of dopamine that is released from the brain into the circulation (Kopin, ).

It has been proposed that plasma HVA concentrations may provide an index of central dopamine metabolism. Summary: Written by leading researchers in the field, Plasma Homovanillic Acid in Schizophrenia provides the most comprehensive and current collection of information on plasma HVA levels to be found anywhere.

It provides a concise synthesis and critique of current data as well as interesting proposals for future research. Plasma levels of homovanillic acid (pHVA), a metabolite of dopamine, were measured in ninety-five Chinese schizophrenic patients free of neuroleptics for at least four weeks.

These patients were treated with classical antipsychotics for six weeks. Pretreatment pHVA was. Plasma homovanillic acid (pHVA) levels were estimated in 20 cases of schizophreniform disorder, 14 cases of schizophrenia 'on medication ' and 17 cases of schizophrenia 'off medication'. A bimodal distribution ofpHVA was seen in schizophreniform disorder subjects, suggesting heterogenous groups in terms of dopaminergic function.

Several lines of evidence indicate altered noradrenergic function in schizophrenia. The authors examined resting, standing, and change (standing minus resting) in plasma norepinephrine levels in 14 drug- free patients with chronic schizophrenia or schizoaffective disorder and in 33 age- and sex-matched healthy volunteers.

Homovanillic acid exists in all living species, ranging from bacteria to humans. Within humans, homovanillic acid participates in a number of enzymatic reactions.

In particular, homovanillic acid and pyrocatechol can be biosynthesized from 3,4-dihydroxybenzeneacetic acid and guaiacol; which is catalyzed by the enzyme catechol O-methyltransferase.

To test this hypothesis, we compared neuroleptic responses between patients with delusional disorder and schizophrenia, measured plasma Cited by: Plasma homovanillic acid (pHVA) levels were estimated in 20 cases of schizophreniform disorder, 14 cases of schizophrenia ‘on medication’ and 17 cases of schizophrenia ‘off medication’.

A bimodal distribution of pHVA was seen in schizophreniform disorder subjects, suggesting heterogenous groups in terms of dopaminergic function. Koreen AR, Lieberman J, Alvir J, Mayerhoff D, Loebel A, Chakos M, Amin F, Copper T.

(): Plasma homovanillic acid levels in first-episode schizophrenia. Arch Gen Psychiatry – CAS Cited by:   In contrast, a fixed dose of haloperidol did not affect those concentrations. Thus, in patients with a diagnosis of schizophrenia, plasma homovanillic Cited by: Pickar D, Labarca R, Doran AR, Wolkowitz OM, Roy A, Breier A, Linnoila M, Paul SM () Longitudinal measurement of plasma homovanillic acid levels in schizophrenic patients: correlation with psychosis and response to neuroleptic treatment.

Arch Gen Psychiatry – Google ScholarCited by: 3. Plasma homovanillic acid (pHVA) and plasma bromperidol concentrations were measured, and psychiatric symptoms were scored.

In the NDS patients, both positive and negative symptoms improved. However, only the positive symptom scores changed in the DS by: 5. 4-hydroxy methoxyphenylacetic acid >98%: Homovanillic acid, which can be found in the barks of Ilex rotunda Thunb, is a neuroendocrine tumor marker. It is also used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain.

Anti-tumorMissing: Schizophrenia. A comparison of plasma homovanillic acid concentrations in schizophrenic patients and normal controls. Arch Gen Psychiatry. Jun; 45 (6)– [Google Scholar] Davis KL, Davidson M, Mohs RC, Kendler KS, Davis BM, Johns CA, DeNigris Y, Horvath TB. Plasma homovanillic acid concentration and the severity of schizophrenic illness.

Science. Under fasting conditions, the dopamine (DA) metabolite homovanillic acid (HVA) in plasma originates mainly from central DA neurons or from central and peripheral noradrenergic (NA) neurons.

The latter source contributes, in addition to HVA, the norepinephrine metabolites, for example, 3-methoxyhydroxyphenylglycol (MHPG).Cited by:   We have developed a novel paradigm involving infusion of the glucose analog, 2-deoxyglucose (2DG), to examine the effects of perturbation on the dopamine metabolite, plasma homovanillic acid (HVA), in schizophrenics and healthy by: Plasma homovanillic acid (pHVA) levels were compared in a large number of neuroleptic-resistant and -responsive schizophrenic patients (male/female=/46) and normal controls (67/27), and correlated with various measures of by: • Plasma homovanillic acid (HVA) levels were measured hourly for a hour period in 10 patients with schizophrenia during treatment with placebo and fluphenazine.

Ten age- and sex-matched normal volunteers were similarly studied. Diet and activity were carefully controlled and monitored in both patients and by:   / A study of the potential confounding effects of diet, caffeine, nicotine and lorazepam on the stability of plasma and urinary homovanillic acid levels in patients with schizophrenia.

In: Biological Psychiatry. ; Vol. 40, No. Cited by: 9. Plasma homovanillic acid concentration was assessed in 60 young schizophrenic patients, with and without first‐degree relatives with schizophrenia, before treatment, and 3 days after starting haloperidol treatment.

The baseline concentration of homovanillic acid in plasma was no different in the two groups before treatment; it was, however, significantly higher in the patients with relatives.

Association of Plasma Homovanillic Acid with Behavioral Symptoms in Patients Diagnosed with Dementia: A Preliminary Report. Biological Psychiatry42 (11), DOI: /S(97) Veli-Pekka Ranta, Arto Urtti, Seppo by: The Effects of Neuroleptics on Plasma Homovanillic Acid.

Arnold J. Friedhoff and Raul R. Silva. If overactivity of the dopaminergic system were the primary etiology of schizophrenia, as was proposed in the early dopamine hypothesis (18) then it would not be possible to understand patients with negative symptoms who have clinical evidence.

The first-episode psychosis group tended to show decreased homovanillic acid, accompanied by an improvement of symptoms. The chronic schizophrenia group showed no alteration of homovanillic acid or 3-methoxyhydroxyphenylglycol over the treatment period.

These results were the same in the dopamine supersensitivity psychosis patients : Masayuki Takase, Hisoshi Kimura, Nobuhisa Kanahara, Yusuke Nakata, Masaomi Iyo. title = "Plasma homovanillic acid concentrations in catatonia", abstract = "We investigated the dopamine metabolite plasma homovanillic acid (plasma HVA) levels in 37 catatonic patients on the day of admission before initial medication as well as in 17 healthy by: To our knowledge, this is the first report of elevated plasma homovanillic acid in cannabis-related psychosis, although we are aware of a report of elevated urinary homovanillic acid following cannabis administration to a volunteer population.

In this small case series of patients with first-episode psychosis associated with cannabis use, plasma homovanillic acid was significantly higher Cited by:   Except for taurine, these amino acids share the L-transport system for neutral amino acids.

In the patients, homovanillic (HVA) acid levels in CSF were decreased and the plasma levels of the amino acids competing with tyrosine and tryptophan for transport into the brain, were all negatively correlated to the CSF concentrations of HVA and 5-HIAA.

Method: A selective and brief review is provided of intensively studied putative markers, including enlarged cerebral ventricles, dopamine D 2 receptor density, amphetamine-stimulated central nervous system dopamine release, plasma homovanillic acid and smooth pursuit eye tracking dysfunction.

Results: A number of biological measures have been Cited by:   Plasma homovanillic acid (HVA), but not plasma 3-methoxy hydroxyphenylglycol (MHPG), was substantially increased in 4 patients undergoing hemodialysis, 3 patients with chronic renal failure, and 3 patients receiving carbidopa/levodopa for Parkinson's disease.

These conditions should be considered in psychiatric research involving plasma HVA. The relationship between pretreatment levels of plasma homovanillic acid (pHVA) and the outcome of dozapine treatment was studied in 18 male patients with schizophrenia who were resistant to treatment with conventional neuroleptics.

After 6 months of clozapine treatment, 7 patients demonstrated ≤20% decrease in the Brief Psychiatric Rating Cited by: texts All Books All Texts latest This Just In Smithsonian Libraries FEDLINK (US) Genealogy Lincoln Collection.

National Emergency Library. Top American Libraries Canadian Libraries Universal Library Community Texts Project Gutenberg Biodiversity Heritage Library Children's Library. Open g: Schizophrenia.Near-infrared spectroscopy and plasma homovanillic acid levels in bipolar disorder: a case report Itaru Miura,1,2 Soichi Kono,1 Sachie Oshima,1 Keiko Kanno-Nozaki,1 Hirobumi Mashiko,1 Shin-Ichi Niwa,1 Hirooki Yabe11Department of Neuropsychiatry, School of Medicine, Fukushima Medical University, Fukushima, Japan; 2Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY.

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